| 摘要 |
Disintegratable tablets for oral administration are made from a three pellet system. One type of pellet contains drug, another is soft and another includes a disintegrant allowing the tablet to disintegrate in the stomach. The drug pellets are preferably coated, for instance with a controlled release binder. The soft pellets preferably contain an ester of a fatty ester. The disintegratable pellets preferably comprise a water-insoluble inorganic powder, such as barium sulphate, iron oxide, magnesium oxide or calcium carbonate. The soft pellets deformed during the tabletting procedure to minimise damage to the drug containing pellets, for instance minimising disruption of the coating. The disintegrant pellets mean the release characteristics from the drug pellets are retained. |
