发明名称 |
A POLYPEPTIDE FROM LUNG EXTRACT WHICH BINDS AMYLOID- beta PEPTIDE |
摘要 |
<p>The present invention provides for a method for inhibiting interaction of an amyloid- beta peptide with a receptor for advanced glycation end product on the surface of a cell which comprises contacting the cell with an agent capable of inhibiting interaction of the amyloid- beta peptide with the receptor for advanced glycation end product, the agent being present in an amount effective to inhibit interaction of the amyloid- beta peptide with the receptor for advanced glycation end product on the surface of the cell. Another embodiment of this invention is a method for evaluating the ability of an agent to inhibit binding of an amyloid- beta peptide with a receptor for advanced glycation end product on the surface of a cell which includes: a) contacting the cell with the agent and amyloid- beta peptide; b) determining the amount of amyloid- beta peptide bound to the cell and c) comparing the amount of bound amyloid- beta peptide determined in step b) with the amount determined in the absence of the agent, thus evaluating the ability of the agent to inhibit the binding of amyloid- beta peptide to the receptor for advanced glycation end product on the surface of the cell.</p> |
申请公布号 |
WO9726913(A1) |
申请公布日期 |
1997.07.31 |
申请号 |
WO1997US00857 |
申请日期 |
1997.01.21 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF |
发明人 |
STERN, DAVID;SCHMIDT, ANN, MARIE;YAN, SHI, DU |
分类号 |
A61K38/00;C07K14/47;C07K14/705;C07K16/28;(IPC1-7):A61K39/395;C07K16/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|