| 摘要 |
The invention provides methods of treating a variety of diseases and conditions by administering an effective amount of an integrin modulating agent, as further defined and specified herein, to an animal suffering from one of the diseases or conditions. The preferred integrin modulating agents are ajoene and disintegrins, variants and analogs of disintegrins. In particular, the invention provides: (1) a method of treating inflammation; (2) methods of treating and preventing viral infections; (3) a method of treating shock; (4) a method of treating arthritis; (5) a method of contraception; (6) a method of suppressing immune responses; (7) a method of treating an autoimmune disease; (8) a method of inhibiting undesirable integrin-mediated cell-cell fusion; (9) a method of inhibiting the formation of lesions; (10) a method of treating psoriasis; (11) a method of treating atherosclerosis; (12) a method of treating diseases or conditions involving a plurality of integrin-dependent etiopathogenetic mechanisms; and (13) a method of inhibiting the transfer of genetic material. |
