| 摘要 |
<p>Process for the preparation of 7-hydroxy taxanes of general formula (I) from 7-trialkylsilyl taxanes of general formula (II), wherein R1 is hydrogen, alkoxy, acyloxy or alkoxyacetoxy, and Z is a hydrogen atom or a radical of general formula (III), wherein R2 is an optionally substituted benzyl radical or an R'2-O-CO- radical wherein R'2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical, R3 is an aromatic alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphthyl or heterocyclyl radical and either R4 is a hydrogen atom and R5 is a hydroxy function protecting group, or R4 and R5 together form a saturated 5- or 6-membered heterocyclic ring. In general formula (II), each R, which are the same or different, is an alkyl radical optionally substituted by a phenyl radical.</p> |
