发明名称 |
SUBSTRATES AND INHIBITORS FOR CYSTEINE PROTEASE ICH-1 |
摘要 |
Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible inhibitors, selectively reversible inhibitors, chromogenic substrates, fluorogenic substrates and radiolabeled substrates/inhibitors. Pharmaceutical compositions comprising the compounds of the invention are also provided. Methods for inhibiting the proteolytic activity of Ich-1, methods for detecting the presence of Ich-1 and methods for isolating Ich-1 using the compounds of the invention are also disclosed. |
申请公布号 |
WO9727220(A2) |
申请公布日期 |
1997.07.31 |
申请号 |
WO1997US01485 |
申请日期 |
1997.01.28 |
申请人 |
BASF AG;PARKE-DAVIS |
发明人 |
TALANIAN, ROBERT, V.;GHAYUR, TARIQ;HODGES, JOHN, C. |
分类号 |
C12N9/99;A61K31/00;A61K38/00;A61K38/55;A61P25/28;A61P43/00;C07K1/22;C07K5/103;C07K7/06;C07K14/81 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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