OPTICAL RESOLUTION OF METHYLPHENIDATE BY 0,0'-BISAROYL TARTARIC ACIDS

摘要

Single isomer methylphenidate, selected from the d- and l-threo-enantiomers, has been obtained in purified form, to the extent of less than 2 % by weight of a contaminant selected from resolving agent and ritalinic acid. This is achieved by resolution of a mixture of enantiomers using an 0,0'diaroyltartaric acid as resolving agent.