NOVEL STEROID CARBAMATES AS POTENTIATING AGENTS

摘要

Novel potentiating steroid carbamates having the general formula (I) ST-OCONR1R2 wherein ST is a steroid or steroid derivative, R1 and R2 are the same or different, or may together form a ring, and R1, R2 is hydrogen or the group (i) wherein A is selected from a bond and an alkyl chain (optionally branched), and B1 and B2 are selected from a bond, a heteroatom such as N, O, S, an alkyl chain (optionally branched), a ring (optionally containing a heteroatom such as N, O, S), and C1, C2, C3 and C4 are selected from hydrogen, an alkyl chain (optionally branched), a carbocyclic/heterocyclic ring system, wherein 1-3 rings may be aromatic (optionally substituted), whereby all of B1 - B2 and C1 - C4 do not need to be present at the same time. Compounds wherein R1 and/or R2 contain an ionizable group can be in the form of addition salts with appropriate pharmaceutically acceptable inorganic or organic counterions. Pharmaceutical compositions comprising steroid carbamates according to formula (I). Methods of treatment comprising administration of steroid carbamates according to formula (I).