| 摘要 |
The invention concerns a compound of formula (I) wherein: R<1> is of the formula -NHC(=O)(1-4C)alkyl, -NHS(O)n(1-4C)alkyl wherein n is 0, 1 or 2 or R<1> is hydroxy; R<2> and R<3> are independently hydrogen or fluoro; R<4> is hydrogen, methyl, ethyl or oxo; R<5> is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or of the formula R<6>(CH2)m- wherein either m is 1-4 and R<6> is, for example, trifluoromethyl, difluoromethyl, fluoromethyl, (1-4C)alkoxy, (1-4C)alkyl S(O)p- wherein p is 0, 1 or 2, (1-6C)alkanoyloxy, di-(<u>N</u>-(1-4C)alkyl)amino, <u>N</u>-((1-4C)alkyl)(1-4C)alkanoylamino, cyano, carboxy, (1-4C)alkoxycarbonyl, carbamoyl, di-(<u>N</u>-(1-4C)alkyl)carbamoyl, <u>N</u>-((1-4C)alkyl)(1-4C)alkanesulphonamido, <u>N</u><1>-((1-4C)alkyl)-di-(<u>N</u><3>-(1-4C)alkyl)ureido, or of the formula -OC(=O)NR<7>(R<8>) or -N(R<9>)SO2NR<7>(R<8>) wherein R<7> and R<8> are independently hydrogen or (1-4C)alkyl and R<9> is (1-4C)alkyl; or m is 2-4 and R<6> is, for example, hydroxy, (1-4C)alkanoylamino, amino, (1-4C)alkylamino, (1-4C)alkanesulphonamido, ureido, di-(<u>N</u><3>-(1-4C)alkyl)ureido or of the formula -NHSO2NR<7>(R<8>); and pharmaceutically-acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.
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