Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same

摘要

The invention provides pyridine derivatives represented by the general formula: <CHEM> wherein R<1> and R<2> may be the same or different from each other and each stand for a hydrogen atom, a C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, (C1-6 alkoxy) carbonyl or carboxyl group or a halogen atom; X stands for a group represented by the formula: -O-, -S-or <CHEM> (wherein R<3> stands for a hydrogen atom or a C1-6 alkyl, phenyl, benzyl or (C1-6 alkoxy)carbonyl group); Z stands for 1 &cir& a group represented by the general formula: -0-(CH2)q-R<5> wherein q stands for an integer of 1 to 3 and R<5> stands for a halogen atom or an (C1-6 alkoxy) carbonyl, aryl or heteroaryl group, 2 &cir& a group represented by the general formula: -0-(CH2)r-0-(CH2)s-0-R<6> wherein r and s each stand for an integer of 1 to 5 and R<6> stands for a hydrogen atom or a C1-6 alkyl group, 3 &cir& a group represented by the formula: <CHEM> 4 &cir& a group represented by the general formula: <CHEM> wherein t stands for an integer of 0 to 2 and A stands for a group represented by the general formula: <CHEM> (wherein B stands for a group represented by the formula: -NH-, -0- or -S-), a C1-6 aklyl, (C1-6 alkoxy)carbonylmethyl, pyridyl or furyl group or a group represented by the general formula: <CHEM> (wherein R<7> stands for a hydrogen atom, a C1-6 alkyl or C1-6 alkoxy group or a halogen atom and w stands for an integer of 0 or 1), 5 &cir& a group represented by the general formula: <CHEM> wherein R<8> stands for an acetoxy or C1-6 alkyl group, n stands for an integer of 0 to 2, m stands for an integer of 2 to 10, and J and K may be the same or different from each other and each stand for a hydrogen atom or a C1-6 alkyl group, and a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising these derivatives are also provided, together with the use of the derivatives for the manufacture of medicaments having therapeutic or preventative value in the treatment of peptic ulcers. Processes for preparing such pyridine derivatives are also provided.