| 发明名称 |
Novel analogs of peptidase substrates |
| 摘要 |
<p>This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with difluoro-methylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced with a terminal amine function, said novel analogs having the property of inhibiting renin and which are useful in the treatment of hypertension. The novel analogs correspond to the formula <CHEM> b</p> |
| 申请公布号 |
GR3023027(T3) |
申请公布日期 |
1997.07.30 |
| 申请号 |
GR19970400694T |
申请日期 |
1997.04.03 |
| 申请人 |
MERRELL PHARMACEUTICALS INC. |
发明人 |
SCHIRLIN, DANIEL |
| 分类号 |
C12N9/99;A61K31/16;A61K31/40;A61K31/4015;A61K31/44;A61K31/4402;A61K31/4418;A61K38/00;A61K38/55;A61P9/12;A61P43/00;C07C271/16;C07C271/18;C07C271/20;C07C271/22;C07C271/50;C07D207/27;C07D213/50;C07D231/38;C07D239/42;C07D295/18;C07K1/113;C07K5/02;C07K5/06;C07K5/08;C07K5/083;C07K5/10;C07K14/81;(IPC1-7):C07K5/08 |
主分类号 |
C12N9/99 |
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