PROCESS FOR PREPARING 2.BETA.-SUBSTITUTED-METHYLPENICILLIN DERIVATIVES

摘要

A process for preparing a 2.beta.-substituted-methylpenicillin compound of the formula (See Fig. I) wherein -N Y is an optionally substituted heterocyclic group containing 2 to 4 nitrogen atoms as the hetero atom in the ring structure, and R1 is a penicillin carboxyl protecting group, the process comprising reacting an azetidinonedisulfide compound of the formula (See Fig. III) wherein R1 is as defined above and R is a substituted or unsubstituted heterocyclic group with a nitrogen-containing heterocyclic compound of the formula (See Fig. IV) wherein (See Fig. V) is as defined above in the presence of a metal compound.