Physiologically active substance well capable of permeating biomembrane

摘要

A physiologically active substance well capable of permeating biomembrane according to the present invention is represented by: <IMAGE> where R represents a residue of a physiologically active substance comprising a peptide, amino acid, aliphatic amine having a phenol skeleton, amino sugar, nucleoside or lactam compound and a residue of physiologically active derivative thereof. The biomembrane permeability of a substance with poor biomembrane permeability can be improved by introducing an adamantyl group to the physiologically active substance.