发明名称 |
(2S)-(5-AMINO-1,2-DIHYDRO-2-METHYL-3-PHENYLPYRIDO[3,4-B] PYRAZIN-7-YL) CARBAMIC ACID, ETHYL ESTER |
摘要 |
The (2S)-(-)isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido¢3,4-b!pyrazin-7-yl)carbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(~)-racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells. The compound, pharmaceutical compositions containing the compound, and a method of ameliorating cancer diseases in mammals are disclosed.
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申请公布号 |
CA1339134(C) |
申请公布日期 |
1997.07.29 |
申请号 |
CA19890595096 |
申请日期 |
1989.03.29 |
申请人 |
SOUTHERN RESEARCH INSTITUTE |
发明人 |
TEMPLE, CARROLL G., JR. |
分类号 |
A61K31/435;A61K31/495;A61P35/00;C07D213/75;C07D213/89;C07D215/22;C07D215/227;C07D471/04;(IPC1-7):A61K31/495 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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