Apparatus and method for random polymer synthesis

摘要

An apparatus and method are provided for the synthesis of compounds, e.g., oligomers or polymers, by the repeated steps of coupling various subunits onto solid supports. The apparatus has for a first member a vessel having chambers opening to a surface of the member, and has for a second member a vessel having a single chamber opening to a surface of the second member. The chambers preferably have filtered apertures to permit passage of gas or liquid while retaining the solid supports in the chambers. The first member is joined with the second member, forming a pair, such that the openings of the first member open into the second member. The first member is used for synthesis reactions and for holding unmixed compounds coupled to solid supports. The second member is used for mixing the solid supports. The solid supports are transferred from one member to another, e.g., by inverting the pair. The chambers of the first member are arranged such that transfer of compound coupled to solid supports from the first member to the second redistributes in a substantially uniform manner.