Pharmaceutically acceptable fixed-dried human blood platelets

摘要

PCT No. PCT/US93/04142 Sec. 371 Date Nov. 28, 1994 Sec. 102(e) Date Nov. 28, 1994 PCT Filed Apr. 28, 1993 PCT Pub. No. WO93/23997 PCT Pub. Date Dec. 9, 1993Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.