发明名称 |
Ob protein derivatives having prolonged half-life |
摘要 |
The present invention concerns long half-life derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives, which have extended half-life as compared to the corresponding native OB proteins. The invention further relates to methods for appetite and/or weight reduction and for treating other physiological conditions by using the long half-life derivatives of OB. |
申请公布号 |
AU1520097(A) |
申请公布日期 |
1997.07.28 |
申请号 |
AU19970015200 |
申请日期 |
1996.12.19 |
申请人 |
GENENTECH, INC. |
发明人 |
FREDERIC J DE SAUVAGE;NANCY LEVIN;RICHARD L VANDLEN |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K38/22;A61K39/395;A61P3/00;A61P3/04;A61P3/10;A61P5/50;C07K14/575;C07K14/705;C07K16/18;C07K19/00;C12N1/21;C12N5/10;C12N15/16;C12N15/70;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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