| 发明名称 |
2',5'-OLIGOADENYLATE DERIVATIVES; COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND CONJUGATES |
| 摘要 |
Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2',5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described. |
| 申请公布号 |
NZ249715(A) |
申请公布日期 |
1997.07.27 |
| 申请号 |
NZ19930249715 |
申请日期 |
1993.02.18 |
| 申请人 |
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
SUHADOLNIK, ROBERT JOSEPH;PFLEIDERER, WOLFGANG |
| 分类号 |
C07H21/04;A61K31/70;A61K31/7088;A61K31/74;A61P31/12;C07H21/00;C07J43/00;C07J51/00;C08B37/00 |
主分类号 |
C07H21/04 |
| 代理机构 |
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