This invention provides an antibody capable of specifically inhibiting the fusion of an HIV-1 envelope glycoprotein<+> cell with an appropriate CD4<+> cell without cross reacting with the HIV-1 envelope glycoprotein or CD4 and capable of inhibiting infection by one or more strains of HIV-1. This antibody is then used to identify a molecule which is important for HIV infection. Different uses of the antibody and the molecule are described.
申请公布号
WO9726009(A1)
申请公布日期
1997.07.24
申请号
WO1997US00758
申请日期
1997.01.17
申请人
PROGENICS PHARMACEUTICALS, INC.;LITWIN, VIRGINIA, M.;ALLAWAY, GRAHAM, P.;MADDON, PAUL, J.
发明人
LITWIN, VIRGINIA, M.;ALLAWAY, GRAHAM, P.;MADDON, PAUL, J.