| 摘要 |
The invention relates to use of a substance or polypeptide according to the formula: X1-X2-X3-Thr-X4-Lys-X5-Arg-X6 (SEQ ID NO:22), wherein X1 is Ala or Gly, X2 is Tyr or Phe, X3, X4 and X5 are independently selected from the group consisting of Met, Ile, Leu and Val; and X6 is selected from the group consisting of Asp, Gln and Glu, optionally at least one of X1, X2, X3, X4, X5 and X6 is independently substituted with non-natural or unusual amino acids and/or the peptide is cyclized and/or the peptide is stabilized and/or the amino terminal amino acid residue is acylated and/or the carboxy terminal amino acid residue is amidated, and peptidomimetics modelled on the basis of the above formula for the preparation of a pharmaceutical composition for the reduction of TNF alpha production. In particular, the invention relates to analogues of peptides of the above formula wherein at least one of X1, X2, X3, X4, X5 and X6 is independently substituted with non-natural or unusual amino acids and/or the peptide is cyclized and/or the peptide is stabilized and/or the amino terminal amino acid residue is acylated and/or the carboxy terminal amino acid residue is amidated, and peptidomimetics modelled on the basis of the above formula.
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