| 发明名称 |
NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS |
| 摘要 |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases. |
| 申请公布号 |
WO9718207(A3) |
申请公布日期 |
1997.07.24 |
| 申请号 |
WO1996US18382 |
申请日期 |
1996.11.13 |
| 申请人 |
DU PONT MERCK PHARMA |
发明人 |
XUE CHU-BIAO;CHERNEY ROBERT JOSEPH;DECICCO CARL PETER;DEGRADO WILLIAM FRANK;HE XIAOHUA;HODGE CARL NICOLAS;JACOBSON IRINA CIPORA;MAGOLDA RONALD LOUIS;ARNER ELIZABETH CATHERINE;DUAN JINGWU;NELSON DAVID J |
| 分类号 |
C12Q1/37;A61K31/00;A61K31/395;A61K31/40;A61K31/407;A61K31/415;A61K31/416;A61K31/4164;A61K31/4178;A61K31/4184;A61K31/42;A61K31/422;A61K31/425;A61K31/427;A61K31/44;A61K31/4427;A61K31/445;A61K31/4465;A61K31/4523;A61K31/495;A61K31/496;A61K31/535;A61K31/5375;A61K31/5377;A61K38/00;A61K49/00;A61P29/00;C07D245/02;C07D255/02;C07D267/00;C07D273/02;C07D291/02;C07D291/08;C07D401/12;C07D403/04;C07D403/12;C07D413/12;C07D417/12;C07D419/12;C07D498/08;C07D521/00;C07K5/02;C07K5/06;C07K5/062;C07K5/065;C07K5/068;C07K5/078 |
主分类号 |
C12Q1/37 |
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