发明名称 |
Process for the preparation of an oxoetiocholenic acid |
摘要 |
The invention is drawn to a process for the preparation of oxoetiocholenic acid of the formula I <IMAGE> by reacting a compound of the formula II <IMAGE> with a halonitrile in the presence of a base followed by formation of a 3-ketone group. The intermediate formed is reacted with an acid of the formula HX in an anhydrous medium followed by dehydrohalogenation of the resulting compound in the presence of a base. The intermediate produced then undergoes alkaline hydrolysis followed by a conventional acid treatment to obtain the compound of formula I.
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申请公布号 |
US5650526(A) |
申请公布日期 |
1997.07.22 |
申请号 |
US19950519772 |
申请日期 |
1995.08.28 |
申请人 |
ROUSSEL UCLAF |
发明人 |
ROUSSEL, PATRICK;VIVAT, MICHEL |
分类号 |
C07J3/00;C07J5/00;C07J21/00;C07J41/00;C07J75/00;(IPC1-7):C07J3/00;C07J7/00 |
主分类号 |
C07J3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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