| 摘要 |
PCT No. PCT/EP97/00084 Sec. 371 Date Jul. 17, 1998 Sec. 102(e) Date Jul. 17, 1998 PCT Filed Jan. 10, 1997 PCT Pub. No. WO97/26244 PCT Pub. Date Jul. 24, 1997The invention relates to quinoline-2-(1H)-one derivatives of the general formula I in which R1, R2 and R3 are in each case independently of one another H, Hal, A or OA; R4 is H, -(CH2)m-NR6R7; R5 is H, -(CH2)n-NR6R7; R6 is H, A or, together with R7, -(CH2)4- or -(CH2)5-; R7 is H, A or -(CH2)m- with a bond to the same ring or adjacent ring B or D or, together with R6, -(CH2)4- or -(CH2)5-; X is -CHR5-, -NR5-, -O-, -S-; A is alkyl having 1-6 C atoms; Hal is F, Cl, Br or I; m is 1-3 and n is 0-3, where at least one of the two radicals R4 or R5 has the meaning -(CH2)m-NR6R7 or -(CH2)n-NR6R7, their enantiomers, stereoisomers, salts and solvates. Such compounds are useful for the treatment of neurodegenerative diseases. |
