Use of toxin peptides and/or affinity handles for the delivering compounds into cells

摘要

A method and compositions for delivering a compound to the cytoplasm of a cell are disclosed. The compound to be delivered may be an antigenic compound, may be linked to a polycationic affinity handle, or both. In one of the methods disclosed, the B moiety of a toxin, such as the anthrax PA polypeptide, is also provided to enhance delivery of the compound to the cytoplasm of the cell.