发明名称 |
ANTITHROMBOTIC AGENTS AND METHODS OF USE |
摘要 |
The present invention provides antithrombotic agents useful for the management of cardiovascular disease. The agents of the subject invention are novel cyclic peptides encompassed by the formula (I): Y-X1-X2-G-D-X3-X4-X5-Z (SEQ ID NO. 1). In said formula, X2 and X3 are independently a hydrophobic amino acid and X4 is a positively charged amino acid. The X1 and X5 substituents are independently zero to five amino acids. The amino and carboxy terminal amino acids of a given peptide can be modified according to the substituents Y and Z, respectively. The peptides are cyclized through a bridge between the two amino acids with the peptide, excluding G, D and X3 in the formation of the bridge. Peptides encompassed by the above formula can be administered in a suitable physiologically acceptable carrier to therapeutically treat thrombosis and conditions resulting from the development of thrombi. |
申请公布号 |
WO9725343(A2) |
申请公布日期 |
1997.07.17 |
申请号 |
WO1997US00385 |
申请日期 |
1997.01.10 |
申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION |
发明人 |
PIERSCHBACHER, MICHAEL, D.;MULLEN, DANIEL, G. |
分类号 |
A61K38/00;A61K31/00;A61P7/02;A61P9/00;A61P9/10;C07K7/06;C07K7/56;C07K7/64;C07K14/75 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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