ANTITHROMBOTIC AGENTS AND METHODS OF USE

摘要

The present invention provides antithrombotic agents useful for the management of cardiovascular disease. The agents of the subject invention are novel cyclic peptides encompassed by the formula (I): Y-X1-X2-G-D-X3-X4-X5-Z (SEQ ID NO. 1). In said formula, X2 and X3 are independently a hydrophobic amino acid and X4 is a positively charged amino acid. The X1 and X5 substituents are independently zero to five amino acids. The amino and carboxy terminal amino acids of a given peptide can be modified according to the substituents Y and Z, respectively. The peptides are cyclized through a bridge between the two amino acids with the peptide, excluding G, D and X3 in the formation of the bridge. Peptides encompassed by the above formula can be administered in a suitable physiologically acceptable carrier to therapeutically treat thrombosis and conditions resulting from the development of thrombi.