发明名称 NOVEL TRICYCLIC COMPOUNDS AND DRUG COMPOSITIONS CONTAINING THE SAME
摘要 Compounds represented by general formula (I) or salts thereof, a process for producing the same, and intermediates therefor, wherein R represents hydroge n or methyl; R1 represents hydrogen, halogeno, hydroxy, benzyloxy, amino, or hydroxymethyl; R2 represents hydrogen, hydroxymethyl, NHR3, SO2NR4R4, or nitro; R6 represents hydrogen or lower alkyl; and X represents nitrogen, oxygen, sulfur, or methylene, provided that when X represents nitrogen, oxygen, or sulfur, then R9 represents hydrogen, one of R7 and R8 represents hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy, and when X represents methylene, then R7 and R8 each represents hydrogen and R9 represents hydrogen, amino, etc. They have a .beta.-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc.
申请公布号 CA2242351(A1) 申请公布日期 1997.07.17
申请号 CA19962242351 申请日期 1996.12.18
申请人 ASAHI KASEI KOGYO KABUSHIKI KAISHA 发明人 MIYOSHI, SHIRO;OGAWA, KOHEI
分类号 A61K31/138;A61K31/343;A61K31/381;A61K31/403;A61P3/04;A61P3/06;A61P3/10;A61P43/00;C07C233/25;C07C275/28;C07C307/10;C07C311/05;C07C311/08;C07C311/37;C07C317/28;C07D209/88;C07D307/91;C07D333/76;(IPC1-7):C07D209/88;C07F7/10;C07C311/13;A61K31/135;A61K31/16;A61K31/18;C07C275/32;A61K31/34;A61K31/38;A61K31/40 主分类号 A61K31/138
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