HIGH AFFINITY MUTANTS OF NUCLEAR FACTOR-INTERLEUKIN 6 AND METHODS OF USE THEREFOR

摘要

The present invention relates to inhibitors of the sequence specific transcription factor nuclear factor IL-6 (NF-IL6) and methods of use therefor. In particular, substitution mutants in the N-terminus of the NF-IL6 tryptic core domain are disclosed that have a higher binding affinity for the DNA binding site than does the wild-type sequence.