| 发明名称 |
COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS |
| 摘要 |
<p>The invention relates to compounds, such as compound (1) in equilibrium with its 4-hydroxy tautomer, and its pharmaceutically acceptable salts. Such compounds are useful as inhibitors of glycinamide ribonucleotide formyl transferase (GARFT) or as antiproliferative agents. The invention also pertains to pharmaceutical compositions and methods employing such compounds as GARFT inhibitors or antiproliferative agents. The invention also relates to compounds useful as intermediates for preparing such compounds.</p> |
| 申请公布号 |
EP0783507(A1) |
申请公布日期 |
1997.07.16 |
| 申请号 |
EP19940925701 |
申请日期 |
1994.07.28 |
| 申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
VARNEY, MICHAEL, D.;ROMINES, WILLIAM, H.;PALMER, CYNTHIA, L. |
| 分类号 |
C07D498/04;A61K;A61K31/195;A61K31/505;A61K31/5383;A61K31/54;A61K31/542;A61K31/555;A61P17/06;A61P29/00;A61P31/00;A61P35/00;A61P37/00;A61P37/06;A61P43/00;C07D;C07D239/00;C07D265/00;C07D279/00;C07D293/00;C07D333/36;C07D333/38;C07D333/40;C07D417/06;C07D513/04;C07D517/04;(IPC1-7):C07D513/04 |
主分类号 |
C07D498/04 |
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