Biocompatible anion exchange materials

摘要

Biocompatible anion exchange materials are provided comprising a support having a quaternary amine moiety and a polyethylene oxide (PEO) moiety having between about 10 and about 200 repeating units covalently bonded thereto, such that said quaternary amine and polyethylene oxide moieties are substantially homogeneously distributed on said support. These anion exchange materials are useful for removing negatively charged species such as heparin from blood and other body fluids without significant removal of platelets. Methods of making and using these materials are also provided.