BICYCLIC HETEROCYCLIC COMPOUND

摘要

N-Alkyl-4-((N-containing bicyclic heterocyclyl)methyl)-phenylacetamide derivatives of formula (I) and their salts are new. A = bicyclic N-heterocyclyl of formula e.g. (A1)-(A7); L, M = H, halogen, CF3, OH, COOH, 3-6C cycloalkyl, OH, phenyl, alkyl, alkoxy or up to 6C alkoxycarbonyl; Q = N or CH; T = SO2, CO, O or S; V = O or S; R<5>-R<8> = H, alkyl, benzyl or phenyl (optionally substituted by halogen or alkyl); R<9> = CF3, benzyl, optionally benzo-fused heterocyclyl (containing 1-3 of S, N and O; and optionally substituted by 1-3 of halogen, Ph, OH, 1-4C alkyl or 1-4C alkoxy) or -S(O)a-R<10>; a = 0-2; R<10> = 1-8C alkyl or 2-8C alkenyl (both optionally substituted by up to 6C acyl, or by up to 10C aryl or aroyl (themselves optionally substituted by 1 or 2 of halogen, CF3 and up to 5C acyl)); or 6-10C aryl (optionally substituted by halogen, OH, CF3, 1-5C alkyl or 1-5C alkoxy); D, E = H, halogen, CF3, OH, COOH, alkyl, alkoxy or up to 6C alkoxycarbonyl; Z = O or S; R<1> = 3-10C cycloalkyl, 1-10C alkyl or phenyl (optionally substituted by 1 or 2 of halogen, CN, OH, 1-4C alkyl or 1-4C alkoxy); R<2> = H or 1-3C alkyl; R<3> = H, 1-5C alkyl or 3-7C cycloalkyl; or phenyl or 5-7 membered heteroaryl (containing 1-3 of S, N and O), both optionally substituted by 1-3 of halogen, NO2, Ph, OH, alkyl or alkoxy; R<4> = H, CH2OH or CH2OCOR<11>; R<11> = H, 1-8C alkyl or phenyl (optionally substituted by 1-3 of halogen, OH, CN, 1-4C alkyl and 1-4C alkoxy); alkyl moieties have 1-6C unless specified otherwise.