发明名称 |
Amine preparation |
摘要 |
A method of making (R)-N-[1-(3-methoxyphenyl)ethyl]-3-(2-chlorobenzene)propanamine which involves reducing the appropriate amidyl or iminyl precursor with an appropriate reducing agent. The appropriate amidyl or iminyl precursor is made from a synthesis involving the use of (R)-3-methoxy- alpha -methylbenzylamine. A method of condensing a nitrile with a primary or secondary amine to form an imine involves the reaction of a nitrile with diisobutylaluminum hydride; and then reacting the resultant compound with a primary or secondary amine to form the imine. The process is especially useful for producing enantiomerically pure chiral imines, and, ultimately, amines. Typical such imines have the formula: <IMAGE> wherein R, R1, R2 and R3 are independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, aryl and aralkyl.
|
申请公布号 |
US5648540(A) |
申请公布日期 |
1997.07.15 |
申请号 |
US19950446491 |
申请日期 |
1995.05.22 |
申请人 |
NPS PHARMACEUTICALS, INC. |
发明人 |
VANWAGENEN, BRADFORD C.;DUFF, STEVEN R.;NELSON, WILLIAM A.;D'AMBRA, THOMAS E. |
分类号 |
C07C213/10;C07C217/58;C07C233/22;(IPC1-7):C07C209/50;C07C209/52 |
主分类号 |
C07C213/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|