Method for making intermediates useful in the synthesis of retroviral protease inhibitors
摘要
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.
申请公布号
US5648511(A)
申请公布日期
1997.07.15
申请号
US19950452187
申请日期
1995.05.25
申请人
G.D. SEARLE & CO.
发明人
NG, JOHN S.;PRZYBYLA, CLAIRE A.;MUELLER, RICHARD A.;VAZQUEZ, MICHAEL L.;GETMAN, DANIEL P.;FRESKOS, JOHN J.;DECRESCENZO, GARY A.;BERTENSHAW, DEBORAH E.;HEINTZ, ROBERT M.;ZHANG, SUHONG;LIU, CHIN;LANEMAN, SCOTT A.