发明名称 Detection of inherited and somatic mutations of APC gene in colorectal cancer of humans
摘要 Methods are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. APC is a tumor suppressor.
申请公布号 US5648212(A) 申请公布日期 1997.07.15
申请号 US19940289548 申请日期 1994.08.12
申请人 THE JOHN HOPKINS UNIVERSITY;UNIVERSITY OF UTAH;JAPANESE FOUNDATION FOR CANCER RESEARCH CANCER INSTITUTE;ZENECA LIMITED 发明人 ALBERTSEN, HANS;ANAND, RAKESH;CARLSON, MARY;GRODEN, JOANNA;HEDGE, PHILIP JOHN;JOSLYN, GEOFF;KINZLER, KENNETH;MARKHAM, ALEXANDER;NAKAMURA, YUSUKE;THLIVERIS, ANDREW;VOGELSTEIN, BERT;WHITE, RAYMOND L.
分类号 C07K14/47;C07K14/82;C07K16/32;C12N5/12;C12N15/12;C12Q1/68;(IPC1-7):C07H21/04;C07H21/02;C12P19/34 主分类号 C07K14/47
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