摘要 |
<p>PROBLEM TO BE SOLVED: To provide a new compound having strong angiotensin II antagonistic action, hypotensive action and central nervous action and useful for the treatment of circulatory diseases such as hypertension, cardiac diseases, cerebral apoplexy, nephritis and arteriosclerosis, Alzheimers disease, senile dementia, etc. SOLUTION: This compound is expressed by the formula I [R<1> is a (substituted)hydrocarbon group which may be bonded through hetero-atom; R<2> is a (substituted)heterocyclic residue having a ring-constituting group; X is bonded to rings Y and W; W and Y are each a (substituted)aromatic hydrocarbon residue which may contain hetero-atom or a heterocyclic residue; (n) is 1 or 2; (a) and (b) are each a (substituted)C or a hetero-atom; (c) is a (substituted)C, a hetero-atom, etc.], e.g. 2-ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4- thiadiazol-3-yl)biphenyl-4-yl]methy]benzimidazole-7-carboxylic acid. The compound of the formula I can be produced by reacting a compound of the formula II with a compound of the formula III (L is a halogen) and, as necessary, properly subjecting the reaction product to hydrolysis, reduction, halogenation, O-, N- or S-alkylation, nucleophilic reaction, cyclization, acylation, etc.</p> |