摘要 |
The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): <IMAGE> (I) wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R2, R3, R4, and R5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R6, R7, R8, and R9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C-R11 (wherein R11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen), or a pharmaceutically acceptable salt thereof as an active ingredient.
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申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
FUJIWARA, SHIGEKI;MACHII, DAISUKE;TAKAI, HARUKI;NONAKA, HIROMI;KASE, HIROSHI;YAO, KOZO;KAWAKAGE, MICHIYO;KUSAKA, HIDEAKI;KARASAWA, AKIRA |