摘要 |
A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids. |
申请人 |
THE PERKIN-ELMER CORPORATION |
发明人 |
CATHCART, G., RICHARD;BRENNAN-MARQUEZ, THOMAS;BRIDGHAM, JOHN, A.;GOLDA, GEORGE, S.;GUIREMAND, HARRY, A.;HANE, MARIANNE;HOFF, LOUIS, BEN;LACHENMEIER, ERIC;KRONICK, MELVYN, N.;KEITH, DOUGLAS, H.;MAYRAND, PAUL, ERIC;METZKER, MICHAEL, L.;MORDAN, WILLIAM, J.;MCBRIDE, LINCOLN, J.;SHIGEURA, JOHN;TING, CHEN, HANSON;WHITELEY, NORMAN, M. |