发明名称 |
HUMAN CALCITONIN-RELATED PEPTIDE |
摘要 |
There is described human calcitonin gene related peptide. A peptide of the structure Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Argi -Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly- -Val-Val-Lys-Asn-Phe-Val-Pro-Thr-Asn- -Val-Gly-Ser-Lys-Ala-Phe-amide(I) is prepared either by chemical synthesis or by the use of recombinant DNA techniques. The peptide has potent biological activity on the cardiovascular function and it is described for use as a pharmaceutical in the treatment of hypertension. A pharmaceutical composition including the peptide is described either as an injectable composition or in a slow release system. Reagents for use in the immunoassay of the peptide are described as is a DNA hybridisation probe for use in an assay for a nucleotide coding for the peptide. |
申请公布号 |
JPH09183798(A) |
申请公布日期 |
1997.07.15 |
申请号 |
JP19960262196 |
申请日期 |
1996.10.02 |
申请人 |
CELLTECH LTD |
发明人 |
KUREIGU ROJIYAA KINGUDON;EDOBURUTSUKU MAAKU ROBAATO |
分类号 |
A61K35/74;A61K38/00;A61K38/23;A61K39/00;A61K39/395;A61P9/08;A61P9/12;A61P43/00;C07K1/113;C07K1/20;C07K5/10;C07K7/06;C07K7/08;C07K14/435;C07K14/575;C07K14/585;C07K16/00;C07K19/00;C12N1/21;C12N15/09;C12P21/02;C12Q1/68;C12R1/19;G01N33/50;G01N33/531;G01N33/58;(IPC1-7):C07K14/585 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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