Protected biopolymers for oral administration and methods of using same

摘要

The present invention provides a composition comprising an ion exchange resin and a therapeutically active biopolymer in a form for oral administration. The present invention also provides a composition comprising Amberlite TM IRP-64 and a cytokine regulatory agent having the amino acid sequence: Ac-Nle-Gln-His-(D)Phe-Arg-(D)Trp-Gly-NH2, in a form for oral administration. The present invention further provides a method of protecting a therapeutically active biopolymer from degradation by forming a complex of the biopolymer and an ion exchange resin. In addition, the present invention provides a method of reducing or inhibiting the severity of a pathological condition by orally administering a therapeutically effective dose of the composition.