摘要 |
A composition suitable for topical administration in treatment of a hyperproliferative skin disease which is a gel comprising (A) a compound of formula <CHEM> wherein A1 and A2 are each independently of the other hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, acyl, lower alkylsulfonyl or arylsulfonyl; or wherein A1 and A2 together form unsubstituted or lower alkyl- or hydroxy-substituted lower alkylene; Ar1 and Ar2 are each independently of the other aryl, heteroaryl or unsubstituted or substituted cycloalkyl; the group -C(=X)- is -C(=O)-, -C(=S)-, -CH2- or -C(=CR1R2)- wherein R1 and R2 are each independently of the other hydrogen or lower alkyl; and R is hydrogen, lower alkyl, aryl-lower alkyl, aryl, amino, hydroxy or lower alkoxy; with the proviso that R is other than phenyl when A1 and A2 are hydrogen, Ar1 and Ar2 are phenyl and the group -C(=X)- is -C(=O)-; or a pharmaceutically acceptable salt thereof when a salt-forming group is present; (B)a C1-C4 alkyl monoether of diethyleneglycol, (C) a gelling agent and (D) a solvent which is miscible with (B). |