| 摘要 |
PROBLEM TO BE SOLVED: To obtain a gonadotropin derivative improved in stability, comprisingα-subunits andβ-subunits having non-natural disulfide bridges. SOLUTION: This gonadotropin comprisesα-subunits andβ-subunits having non-natural disulfide bridges, preferably non-natural disulfide bridges between the subunits, e.g. (Metα-29 Cys-Metβ-41. Cys), (Tyrα-37 Cys-Iieβ-33 Cys), etc., in human lutenizing hormone, and (Metα-29 Cys-Metβ-41 Cys), (Tyrα-37 Cys-Iieβ-33 Cys), etc., in human hormone for stimulating villi sex glands. And a medicine composition containing the gonadotropin. |
