发明名称 |
Bile acid inhibitors of metalloproteinase enzymes |
摘要 |
The present invention relates to a bile acid derivative, which comprises a bile acid derivatized at the carboxyl group with a hydroxamic acid or hydroxamate ester. The carboxyl group in the bile acid compound can also be derivatized with an amino acid or oligopeptide, whose C-terminus is derivatized with a hydroxamic acid or a hydroxamate ester. The present invention also relates to a method of use of a bile acid or a bile acid derivative to inhibit a metalloproteinase enzyme, comprising contacting a metalloproteinase with an effective amount of a bile acid or bile acid derivative. In another embodiment, the present invention further relates to a method of use of a bile acid or bile acid derivative to therapeutically treat a disease, which is ameliorated by inhibiting a metalloproteinase enzyme. In this method, a therapeutically effective amount of a bile acid, a bile acid derivative or physiologically acceptable salts thereof, is administered to a human or other mammal.
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申请公布号 |
US5646316(A) |
申请公布日期 |
1997.07.08 |
申请号 |
US19950430129 |
申请日期 |
1995.04.25 |
申请人 |
OSTEOARTHRITIS SCIENCES, INC. |
发明人 |
JACOBSON, ALAN R.;GABLER, DOUGLAS G.;OLEKSYSZYN, JOZEF |
分类号 |
C07J41/00;(IPC1-7):C07J9/00 |
主分类号 |
C07J41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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