发明名称 |
Therapeutic antibody based fusion proteins |
摘要 |
The present invention relates to methods of providing a targeted, amplified antitumor immune response using antibody-based fusion proteins. More specifically, the invention relates to the use of antibody-based fusion proteins comprising an immunoglobulin portion capable of binding to a tumor antigen linked to a biologically active lymphokine. The immunoglobulin portion targets the fusion protein to the site of the tumor cells and the lymphokine portion stimulates the proliferation of immune T cells at the site of the tumor cells, thereby amplifying the anti-tumor immune response. In preferred embodiments of the invention, the immunoglobulin portion of the fusion protein is derived from the L6 monoclonal antibody and/or the lymphokine is interleukin-2.
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申请公布号 |
US5645835(A) |
申请公布日期 |
1997.07.08 |
申请号 |
US19940247437 |
申请日期 |
1994.05.23 |
申请人 |
ONCOGEN |
发明人 |
FELL, JR., HENRY PERRY;GAYLE, MARGIT ANN |
分类号 |
A61K38/00;A61K39/395;A61K47/48;A61P35/00;C07K14/00;C07K14/46;C07K14/52;C07K14/54;C07K14/55;C07K16/00;C07K16/30;C07K16/46;C07K19/00;C12N15/09;C12P21/02;C12P21/08;C12R1/91;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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