PROTEIN ESTIMATED TO BIND TO ATP AND NUCLEIC ACID AND HAVE PROPERTIES OF HELICASE AND ATPASE

摘要

Nucleic acid binding protein (I) with helicase activity, the mRNA of which (or its translation products) are strongly expressed in presence of leflunomide (II, i.e. 4-(N-(4-trifluoromethylphenyl)-5-methyl-isoxazole)) or compounds with similar activity is new. Also new are: (1) DNA (III) encoding (I), or parts of it, and sequences that hybridise under stringent conditions with (III); (2) vectors containing (III) or sequences antisense to (III) and (3) host cells containing (III) or the vectors.