CASCADE POLYMER COMPLEXES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICALS CONTAINING THE SAME

摘要

Cascade polymer complexes contain: (a) complexing ligands of general formula (I), in which A stands for a nitrogenated cascade core of basic multiplicity a; X and Y independently represent a direct bond or a cascade reproduction unit of reproduction multiplicity x or y; Z and W independently represent a cascade reproduction unit of reproduction multiplicity z or w; K stands for a complexing agent residue; a equals 2 to 12; x, y, z and w independently represent the integers 1 to 4, provided that at least two reproduction units be different, that 161.x.y.z.w64 applies to the product of the multiplicities and that at least one of the cascade reproduction units X, Y, Z, W stand for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane reproduction unit; (b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83; optionally (c) cations of inorganic and/or organic bases, amino acids or amino acid amides; and (d) optionally acylated terminal amino groups. These compounds are useful in diagnosis and therapy.