摘要 |
The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's diseae, Parkinson's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, chronic pain, glaucoma, CMV retinitis, urinary incontinence and inducing anesthesia, as well as for enhancing cognition, treating or preventing opiate tolerance, treating or preventing aminoglycoside antibiotic induced hearing loss, and treating opiate withdrawal.
|
申请人 |
STATE OF OREGON, ACTING BY AND THROUGH THE OREGON;ACEA PHARMACEUTICALS, INC.;COCENSYS, INC.;CAI, SUI, XIONG;KEANA, JOHN, F., W.;LAN, NANCY, C.;ARALDI, GIAN, LUCA;TAMIZ, AMIR;ZHOU, ZHANG-LIN;WOODWARD, RICHARD, M.;WHITTEMORE, EDWARD, R.;WEBER, ECKARD |
发明人 |
CAI, SUI, XIONG;KEANA, JOHN, F., W.;LAN, NANCY, C.;ARALDI, GIAN, LUCA;TAMIZ, AMIR;ZHOU, ZHANG-LIN;WOODWARD, RICHARD, M.;WHITTEMORE, EDWARD, R.;WEBER, ECKARD |