A NOVEL RECEPTOR-TYPE TYROSINE KINASE AND USE THEREOF

摘要

The present invention relates generally to a novel receptor-type tyrosine kinase, to genetic sequences encoding same and to uses therefor. More particularly, the present invention contemplates a receptor-type tyrosine kinase having the following properties: (i) belongs to the Eph subfamily of RTKs as determined by conserved cysteine residues and fibronectin type III repeats; (ii) comprises protein tyrosine kinase catalytic domain motifs; and (iii) comprises an amino acid sequence substantially as set forth in SEQ ID NO: 2 or having at least about 79 % similarity thereto.