发明名称 |
PROCESS FOR 6-O-ALKYLATION OF ERYTHROMYCIN DERIVATIVES |
摘要 |
A procedure for preparing 6-O-alkyl erythromycin compounds having the formula: <IMAGE> wherein R1 is a loweralkyl group, R2 and R3 are independently hydrogen or a hydroxy-protecting group, except that R2 and R3 may not both be hydrogen simultaneously; Y is oxygen or a specifically substituted oxime; and Z is hydrogen, hydroxy or protected-hydroxy; by reaction of the compound wherein R1 is hydrogen with an alkylating reagent, in the presence of a strong alkali metal base and also in the presence of a weak organic amine base, in a suitable stirred or agitated polar aprotic solvent, or a mixture of such polar aprotic solvents maintained at a reaction temperature and for a period of time sufficient to effect alkyation. |
申请公布号 |
WO9719096(A3) |
申请公布日期 |
1997.07.03 |
申请号 |
WO1996US17017 |
申请日期 |
1996.10.25 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
LIU, JIH-HUA;FOSTER, GEORGE, A., JR.;MONTGOMERY, STEPHEN, H. |
分类号 |
C07H17/08 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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