| 摘要 |
PCT No. PCT/EP94/01978 Sec. 371 Date Dec. 20, 1995 Sec. 102(e) Date Dec. 20, 1995 PCT Filed Jun. 17, 1994 PCT Pub. No. WO95/01353 PCT Pub. Date Jan. 12, 1995Disclosed are the compounds of formula I xy or lower alkoxy and one hydrogen, or two hydrogens; Ra and Rb independently represent hydrogen, hydroxy, lower alkoxy, nitro, amino or halogen; or Ra and Rb on adjacent carbons taken together represent lower alkylenedioxy; Rc represents hydrogen, lower alkyl or aryl-lower alkyl; R represents hydrogen or acyl; R1 represents hydrogen, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, biaryl, biaryl-lower alkyl or trifluoromethyl; R2 represents hydrogen or lower alkyl; or R1 and R2 together with the carbon to which they are attached represent cycloalkylene or benzo-fused cycloalkylene; m represents one or two; n represents zero or one; COOR3 represents carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester; disulfide derivatives formed from said compounds wherein R is hydrogen; and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; methods for preparation of said compounds; intermediates; and methods of treating disorders in mammals which are responsive to ACE and NEP inhibition by administration of said compounds to mammals in need of such treatment.
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