发明名称 |
Daunomycin derivative with reduced cytotoxicity toward normal cells |
摘要 |
Chemotherapeutic agents that exhibit cytotoxicity similar to that of daunomycin against cancer cells, but exhibit lessened cytotoxicity against normal, non-transformed cells are disclosed, as are compositions, processes for making and using the same. A contemplated chemotherapeutic agent is a daunomycin derivative whose structure corresponds to structural Formula I, wherein Ar is phenyl, 1-naphthyl or 2-naphthyl <IMAGE> I
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申请公布号 |
US5643887(A) |
申请公布日期 |
1997.07.01 |
申请号 |
US19950423266 |
申请日期 |
1995.04.17 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
NICOLAOU, KYRIACOS C.;WRASIDLO, WOLFGANG A.;MALIGRES, PETER E. |
分类号 |
C07H15/252;(IPC1-7):A61K31/70 |
主分类号 |
C07H15/252 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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