| 摘要 |
PCT No. PCT/JP93/00549 Sec. 371 Date Oct. 27, 1994 Sec. 102(e) Date Oct. 27, 1994 PCT Filed Apr. 27, 1993 PCT Pub. No. WO93/22313 PCT Pub. Date Nov. 11, 1993A nitrogen-containing tricyclic compound represented by formula (I): <IMAGE> (I) a salt thereof, or a solvate of said compound or said salt, wherein R represents phenyl or naphthyl group which is unsubstituted or substituted at one to five sites with a group such as a halogen atom; a straight chain or branched alkyl group containing 1 to 10 carbon atoms which is unsubstituted or substituted with one or more halogen atoms; or the like; Y represents hydrogen atom; and Z represents a group such as hydrogen atom, hydroxyl group, or the like; or Y and Z together represent a group such as hydrazono group, hydroxyimino group, or the like which is unsubstituted or substituted with a particular group; and X1-X2 DIFFERENCE C DIFFERENCE X3 represents CH-N-C=C or N-C=C-N; provided that when X1-X2 DIFFERENCE C DIFFERENCE X3 represents N-C=C-N, Y and Z does not together represent hydroxyimino group or oxygen atom; is capable of inhibiting the production of IgE antibody, and therefore, is useful as a prophylactic and/or therapeutic agent for allergic diseases.
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